Potencial nutraceútico da Myrciaria dubia na prevenção de enfermidades associadas a inflamação crônica e síndrome metabólica

Abstract

Camu-camu is a promising nutraceutical fruit for helping various diseases with high prevalence and high mortality. This doctoral thesis aims to highlight the actions of camu-camu in inflammatory, metabolic and proliferative disorders such as metabolic and tumor syndrome. The first chapter presents the actions of camu-camu on comorbidities that are components of metabolic syndrome, through a clinical study, the results of the effects of camu-camu were exposed, showing an improvement in some laboratory and anthropometric indices of patients with metabolic syndrome. Chapter 2 presents the main bioactive compounds of camu-camu in combating factors associated with obesity; the main mechanisms of action and bioactive properties of camu-camu in controlling excess body fat and changes in glucose and lipid metabolism were identified. Chapter 3 presents the action of bioactive compounds from camucamu (Myrciaria dubia) on tumor cells, showing principles and studies that demonstrated their cytoprotective and DNA repair action. The fourth chapter discusses the market potential for camu-camu in the Amazon region, in relation to sustainable use of products based on this fruit. Chapter 5 presents the freeze-drying of camu-camu as an alternative for consumption and better conservation, presenting reports on the process of making standardized freeze-dried powder from camu-camu pulp. All the works somehow converge on information that highlights the potential of this fruit in people's health, pointing out an important alternative in the therapy of diseases with high mortality such as metabolic and neoplastic syndrome, highlighting its bioactive compounds and characteristics associated with the improvement of associated factors. to these illnesses, also discussing the obstacles to consuming the fruit in natura and proposing handling, conservation and consumption solutions.